INTRODUCTION

The Measles IgG/IgM Rapid Test Cassette is a lateral flow chromatographic immunoassay for the qualitative detection of IgG and IgM antibodies to Measles in serum or plasma to aid in the diagnosis of Measles infection.

INTENDED USE

Measles (Rubeola) is a highly contagious viral disease resulting from infection with a paramyxovirus (genus Morbillivirus). Eight to twelve days following infection, a prodromal phase of measles begins, which is marked by fever, cough, coryza, and conjunctivitis. In many cases, the onset of the prodromal symptoms is followed (2 – 3 days) by the appearance of a specific enanthem (Koplik’s spots), and a generalized maculopapular eruption (3 – 4 days after onset). In uncomplicated measles, the appearance of the rash is followed by a peak in temperature one to two days later, and a rapid defervescence on the third or fourth day of the rash. Under normal circumstances, the appearance of the prodromal symptoms, especially the highly specific and pathognomic Koplik’s spots, is sufficient for clinical diagnosis. However, since the introduction of the measles vaccine in 1963, the incidence of measles has dramatically decreased. As a result, medical professionals have had less experience in the clinical diagnosis of the disease and may require laboratory assistance for confirmation.